Mymetics Corp (MYMX)

[bow-tie]

The invention discloses an influenza Virosome (VI) -coated bionic nano vaccine and a preparation method thereof, the bionic nano vaccine comprises an influenza virosome, small-particle-size fluorinated particles and a DNA vaccine, the bionic nano vaccine is a core-shell structure nano system, VI is a lipid vesicle containing influenza virus envelope protein, the inner core of the nano system is the small-particle-size fluorinated particles loaded with the DNA vaccine, and the influenza virosome is coated on the surface of the inner core. The virosome of the invention has the receptor binding activity, the lysosome membrane fusion activity and the antigen activity of influenza virus; the small particle size of the fluorinated inner core can deliver DNA into the core and promote protein expression. The nano system can realize the joint loading of the protein vaccine and the DNA vaccine and the site-specific delivery of each component, and finally obtains a synergistic effect to improve the immune effect. The invention belongs to the field of pharmaceutical preparations and the technical field of biological medicines, can effectively prevent influenza virus infection, and has high clinical application value.


https://patents.google.com/patent/CN110772635A/en